Several chemicals are regarded as exceptionally potent due to their potency. Fentanyl, for example, is one of the most potent medicinal opioids, approximately 50-100 times stronger than morphine. It is used in hospitals to treat severe pain, but it may be quite harmful if overused. In other sectors, medications such as Modafinil and Modalert are recognized for their high alertness and cognitive impacts rather than their physical potency. Overall, the "power" of a medication is determined by its effect on pain, awareness, attention, or other physical processes. Proper medical supervision is always necessary while using powerful drugs.

Sometimes, dietary deficits are connected to oversleeping. Iron deficiency is the most prevalent, and since it lowers blood oxygen delivery, it can lead to weariness and poor energy. Cognitive slowness, weakness, and severe fatigue are other symptoms of vitamin B12 insufficiency. Mood swings and exhaustion have been linked to low vitamin D levels. In certain instances, folate insufficiency also plays a role. But rather than being a result of a lack, oversleeping is frequently linked to thyroid issues, depression, sleep apnea, or persistent stress. Despite using stimulants such as Modvigil 200, chronic fatigue may still be caused by underlying inadequacies.